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Two-photon imaging and selective laser ablation of cochlea hair cells through a multimode fiber probe
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Paper Abstract

We demonstrate multimode fiber probe that accomodates dual modality properties for high power ultrashort pulse delivery. A commercially available multimode graded-index (GRIN) fiber is used for two-photon imaging and/or femtosecond laser ablation of Cochlea hair cells. Lensless focusing and digital scanning of ultrashort pulses through the optical fiber is realized using the transmission matrix technique. We investigate the performance and the limitations of the GRIN probe in terms of focusing efficiency and peak power delivery. Selective laser ablation guided by the twophoton image obtained through the GRIN fiber is realized by proximally-only control of the femtosecond laser beam.

Paper Details

Date Published: 27 February 2019
PDF: 6 pages
Proc. SPIE 10872, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX, 1087206 (27 February 2019); doi: 10.1117/12.2510202
Show Author Affiliations
Eirini Kakkava, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Marilisa Romito, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Damien Loterie, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Konstantina Stankovich, Harvard Medical School (United States)
Christophe Moser, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Demetri Psaltis, Ecole Polytechnique Fédérale de Lausanne (Switzerland)


Published in SPIE Proceedings Vol. 10872:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX
Israel Gannot, Editor(s)

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