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Wide field speckle imaging for the investigation of cerebral blood flow in vivo in murine model of obesity
Author(s): F. Pain; H. Soleimanzad; F. Smekens; C. Magnan; H. Gurden
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Paper Abstract

The morphological and functional changes in cerebral blood vessels network is not well characterized in mice models of obesity. In order to study the hemodynamics of these models at rest and during sensory stimulation, we have developed a multi exposure speckle imaging system. It allows wide field superficial imaging of blood flow of the mice cortex. We have characterized the performances of the system using microfluidic phantoms. The capacity of the technique to retrieve accurate relative flow values was studied as a function of the diameter of vessels and the scatterers concentration. New biological data have been obtained in mice models of obesity (high fat diet mice) at rest and under sensory activation.

Paper Details

Date Published: 1 March 2019
PDF: 7 pages
Proc. SPIE 10865, Neural Imaging and Sensing 2019, 108650V (1 March 2019); doi: 10.1117/12.2510077
Show Author Affiliations
F. Pain, Univ. Paris Saclay (France)
CNRS (France)
H. Soleimanzad, Univ. Paris Saclay (France)
CNRS (France)
F. Smekens, Univ. Paris Saclay (France)
CNRS (France)
C. Magnan, Univ. Paris Diderot (France)
CNRS (France)
H. Gurden, Univ. Paris Diderot (France)
CNRS (France)


Published in SPIE Proceedings Vol. 10865:
Neural Imaging and Sensing 2019
Qingming Luo; Jun Ding; Ling Fu, Editor(s)

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