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Low-cost diagnostic for monitoring neonatal jaundice in low-resource settings (Conference Presentation)
Author(s): Pelham Keahey; Mathieu Simeral; Kristofer Schroder; Meaghan Bond; Prince Mtenthaonnga; Queen Dube; Rebecca Richards-Kortum
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Paper Abstract

Neonatal Jaundice is a common condition in newborns caused by excess bilirubin accumulating in the blood. Bilirubin is a neurotoxin and if left untreated can cause permanent neurological impairment or death. Jaundice resulting from unconjugated hyperbilirubinemia can be easily treated using blue light phototherapy, and several low-cost treatment systems have been built for low-resource settings. However, there is still a lack of an appropriate low-cost diagnostic. To address this, we present BiliSpec, a low-cost paper lateral flow disposable and reader to measure total bilirubin from whole blood. The system can be used at the point-of-care and measure bilirubin concentration within minutes. The accuracy correlates well with a reference laboratory standard (r = 0.996). We then performed a pilot clinical study using BiliSpec at Queen Elizabeth Central Hospital in Blantyre, Malawi. Bilirubin concentrations measured with BiliSpec correlated well with a laboratory reference standard in a 94 patient study (r = 0.973). Bilirubin concentrations measured ranged from 1.1 mg/dL to 23.0 mg/dL. The mean difference between BiliSpec and the laboratory standard was 0.3 mg/dL (95% CI: −1.7–2.2 mg/dL).

Paper Details

Date Published: 4 March 2019
Proc. SPIE 10885, Optical Diagnostics and Sensing XIX: Toward Point-of-Care Diagnostics, 108850M (4 March 2019); doi: 10.1117/12.2510066
Show Author Affiliations
Pelham Keahey, Massachusetts General Hospital (United States)
Mathieu Simeral, Rice Univ. (United States)
Kristofer Schroder, Rice Univ. (United States)
Meaghan Bond, Rice Univ. (United States)
Prince Mtenthaonnga, Queen Elizabeth Central Hospital (Malawi)
Queen Dube, Queen Elizabeth Central Hospital (Malawi)
Rebecca Richards-Kortum, Rice Univ. (United States)

Published in SPIE Proceedings Vol. 10885:
Optical Diagnostics and Sensing XIX: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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