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Instrument for measurement of singlet oxygen for studies of skin under UVA irradiation
Author(s): S. J. Davis; D. I. Rosen; J. England; M. F. Hinds; R. K. Sivamani; W. Burney
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Paper Abstract

In this paper we will describe a non-intrusive, optically-based instrument that can quantitatively measure singlet molecular oxygen, a constituent of reactive oxygen species (ROS) produced by irradiation of human skin by the longer wavelength UV radiation known as UVA. UVA is causally associated with DNA damage and subsequent development of melanoma. We will present data from healthy human subjects that show formation of singlet molecular oxygen and concomitant production of thymine dimers, indicative of DNA damage. We will also discuss how this instrument may be a valuable tool for the development of more effective sunblock formulations for UVA.

Paper Details

Date Published: 26 February 2019
PDF: 10 pages
Proc. SPIE 10851, Photonics in Dermatology and Plastic Surgery 2019, 108510J (26 February 2019); doi: 10.1117/12.2510039
Show Author Affiliations
S. J. Davis, Physical Sciences Inc. (United States)
D. I. Rosen, Physical Sciences Inc. (United States)
J. England, Physical Sciences Inc. (United States)
M. F. Hinds, Physical Sciences Inc. (United States)
R. K. Sivamani, Univ. of California, Davis (United States)
W. Burney, Univ. of California, Davis (United States)

Published in SPIE Proceedings Vol. 10851:
Photonics in Dermatology and Plastic Surgery 2019
Bernard Choi; Haishan Zeng, Editor(s)

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