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Monte Carlo investigation of the effect of skin tissue optical properties on detected Cherenkov emission
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Paper Abstract

In this study, we use Monte Carlo modelling to investigate the effect of tissue optical properties on Cherenkov emission detected from tissue surface. MC simulations are performed for wavelength between 400-1000nm and the values of absorption coefficient at each wavelength are determined based on the molar extinction coefficients of oxy- and deoxy-hemoglobin, with varying total haemoglobin concentration and tissue oxygen saturation of 70%. Tissue reduced scattering coefficient is approximated using μs (λ) = Aλ-0.838. A range of clinically relevant tissue optical properties was investigated, with absorption coefficient between 0.1 and 1 cm-1 and reduced scattering coefficient between 5 and 40 cm-1 at 665nm. The angular distribution, depth of origins and the effect of tissue optical properties on Cherenkov emission on tissue surface are evaluated.

Paper Details

Date Published: 7 March 2019
PDF: 8 pages
Proc. SPIE 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, 108621D (7 March 2019); doi: 10.1117/12.2509854
Show Author Affiliations
Yi Hong Ong, Univ. of Pennsylvania (United States)
Andrew Q. Li, Univ. of Pennsylvania (United States)
Timothy C. Zhu, Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 10862:
Molecular-Guided Surgery: Molecules, Devices, and Applications V
Brian W. Pogue; Sylvain Gioux, Editor(s)

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