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A co-axial projection surgical navigation system for breast cancer sentinel lymph node mapping: system design and clinical trial
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Paper Abstract

Sentinel lymph node biopsy is important in the early stage breast tumor resection surgery. Its results will determine if the axillary lymph node dissection (ALND) will be conducted afterwards. For locating sentinel lymph nodes, indocyanine green (ICG) has been widely used with a near infrared (NIR) camera to image its fluorescence. However, surgeons need to watch a screen beside the operating table to see the fluorescence, with their hands operating on the surgical site. We developed a navigation system that projects the invisible fluorescence back to the surgical site visibly in real-time. The system introduces a co-axial optics design to guarantee the projection accuracy. Phantom experiments are conducted to assess the projection resolution and accuracy of the system. Animal experiments with three mice show a good system performance and its preclinical feasibility. Furthermore, the system is tested in a clinical trial of ninety breast cancer patients in three hospitals in China. ICG and methylene blue (MB) is subcutaneously injected separately into the areola at 3-4 points to get both fluorescent and visible contrast, for further comparison. The navigation process is compared with a commercialized NIR imaging system. The results show a 100% detection rate of sentinel lymph nodes and a good consistency with the methylene blue and the commercialized imaging device. The experiments demonstrate good clinical feasibility of the co-axial projection system.

Paper Details

Date Published: 26 February 2019
PDF: 6 pages
Proc. SPIE 10868, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII, 108680N (26 February 2019); doi: 10.1117/12.2509852
Show Author Affiliations
Peng Liu, Univ. of Science and Technology of China (China)
Pengfei Shao, Univ. of Science and Technology of China (China)
Jianmin Ma, Sino-Medic Co., Ltd. (China)
Min Xu, Sino-Medic Co., Ltd. (China)
Chenmeng Li, Univ. of Science and Technology of China (China)

Published in SPIE Proceedings Vol. 10868:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII
Anita Mahadevan-Jansen, Editor(s)

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