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Diagnostic possibilities of dynamic light scattering technique
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Paper Abstract

The latest tendencies in individual diagnostics show high interest in development of optical methods. We have used a dynamic light scattering technique to study the size composition of proteins in blood serum of donors with different diseases. In this work, we focused our attention on demonstration of differences between size compositions of blood serum of donors with different types of diseases. It had been found that the proteins' size composition for sick donors differs in a certain way from the size map of healthy donors. Specifically, the relative concentrations of albumins, globulins and circulating immune complex can be used as a diagnostic parameter as it changes significantly on the disease. This result shows the possibilities of application of dynamic light scattering technique to analyze progress and stage of different diseases, in particular, immune diseases and oncology. We declare that the proposed dynamic light scattering technique can be used in medical practice for early fast and simple diagnostics.

Paper Details

Date Published: 5 March 2019
PDF: 8 pages
Proc. SPIE 10891, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI, 108910J (5 March 2019); doi: 10.1117/12.2509847
Show Author Affiliations
Elina Nepomnyashchaya, Saint-Petersburg State Polytechnical Univ. (Russian Federation)
Elena Velichko, Saint-Petersburg State Polytechnical Univ. (Russian Federation)
Tatyana Bogomaz, Saint-Petersburg State Polytechnical Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 10891:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI
Dan V. Nicolau; Dror Fixler; Ewa M. Goldys, Editor(s)

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