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Development of local surface plasmon resonance sensor using gold nanoparticles
Author(s): Marianna Beiderman; Menachem Motiei; Rachela Popovtzer; Dror Fixler
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Paper Abstract

The healthcare industry is moving towards personalized medicine and patients seek greater role in their care. In this paper we describe a proof of concept of versatile optical sensor that potentially can be used for in vivo detection of biological events. The developed sensor comprises of a silver thin film glass slide and gold nanoparticles (GNPs) and allows detection of chemical changes using surface plasmon resonance (SPR), local surface plasmon resonance (LSPR) and fluorescence lifetime detection modalities. A change in spectrum was observed after removal of GNPs by 2-mercaptoethanol. Moreover, GNP conjugated to fluorescein were tested using fluorescence lifetime microscopy (FLIM) to enhance sensing capabilities and provide additional dimension for detection. The sensor has the potential to provide real-time analyses of different biological molecules, such as antibody and antigen, receptor and ligand, and complementary DNA fragments.

Paper Details

Date Published: 5 March 2019
PDF: 8 pages
Proc. SPIE 10891, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI, 108910O (5 March 2019); doi: 10.1117/12.2509667
Show Author Affiliations
Marianna Beiderman, Bar-Ilan Univ. (Israel)
Menachem Motiei, Bar-Ilan Univ. (Israel)
Rachela Popovtzer, Bar-Ilan Univ. (Israel)
Dror Fixler, Bar-Ilan Univ. (Israel)

Published in SPIE Proceedings Vol. 10891:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI
Dan V. Nicolau; Dror Fixler; Ewa M. Goldys, Editor(s)

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