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Imaging of human peripheral blood vessels during cuff occlusion with a compact LED-based photoacoustic and ultrasound system
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Paper Abstract

Non-invasive imaging plays an important role in diagnosing and monitoring peripheral artery disease (PAD). Doppler ultrasound imaging can be used for measuring blood flow in this context. However, this technique frequently provides low contrast for flow in small vessels. Photoacoustic imaging can allow for the visualization of blood in small vessels, with direct contrast from optical absorption of hemoglobin. In this work, we investigate the potential applications of a compact LED-based photoacoustic (850 nm) and ultrasound imaging system for visualizing human peripheral blood vessels during cuff occlusion. Each measurement comprised three stages. First, a baseline measurement of a digital artery of a human finger from a volunteer without a diagnosis of PAD was performed for several seconds. Second, arterial blood flow was stopped using an occlusion cuff, with a rapid increase of pressure up to 220 mm Hg. Third, the occlusion cuff was released rapidly. Raw photoacoustic and ultrasound image data (frame rate: 70 Hz) were recorded for the entire duration of the measurement (20 s). The average photoacoustic image amplitude over an image region that enclosed the digital artery was calculated. With this value, pulsations of image amplitudes from the arteries was clearly visualized. The average photoacoustic image amplitude decreased during the increase in cuff pressure and it was followed by a rapid recovery during cuff release. With real-time non-invasive measurements of peripheral blood vessel dynamics in vivo, the compact LED-based system could be valuable for point-of-care imaging to guide treatment of PAD.

Paper Details

Date Published: 27 February 2019
PDF: 5 pages
Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 1087804 (27 February 2019); doi: 10.1117/12.2509666
Show Author Affiliations
Wenfeng Xia, King's College London (United Kingdom)
Univ. College London (United Kingdom)
Efthymios Maneas, Univ. College London (United Kingdom)
Nam Trung Huynh, Univ. College London (United Kingdom)
Mithun Kuniyil Ajith Singh, Cyberdyne, Inc. (Netherlands)
Nina Montana Brown, Univ. College London (United Kingdom)
Sebastien Ourselin, King's College London (United Kingdom)
Edward Gilbert-Kawai, Institute of Sport, Exercise and Health (United Kingdom)
Simeon J. West, Univ. College Hospital (United Kingdom)
Adrien E. Desjardins, Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 10878:
Photons Plus Ultrasound: Imaging and Sensing 2019
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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