Share Email Print
cover

Proceedings Paper • new

3D imaging in microfluidics: new holographic methods and devices
Author(s): V. Bianco; L. Miccio; P. Memmolo; F. Merola; B. Mandracchia; T. Cacace; M. Mugnano; M. Paturzo; M. Villone; P. L. Maffettone; P. Ferraro
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

In global healthcare and point-of-care diagnostics there is an increasing request of medical equipment with devices able to provide fast and reliable testing for clinical diagnosis. In developing countries that lack of adequate facilities, this need is even more urgent. Lab-on-a-Chip devices have undergone a great growth during the last decade, supported by optical imaging techniques more and more refined. Here we present recent progresses in developing imaging tools based on holographic microscopy that can be very useful when applied into bio-microfluidics. Digital Holography (DH) is label-free, non-invasive, potentially high-throughput and, above all, quantitative. We show the recent advancements of DH in transmission microscopy mode, when this is applied to microfluidics to yield 3D imaging capabilities. Holographic flow cytometry through quantitative phase imaging and in-flow tomography for the analysis and manipulation of micro-particles and cells will be shown [1-3]. Medical diagnostic applications based on DH will be also shown. Moreover, we present a portable common-path holographic microscope embedded onboard a microfluidic device that paves the way to the application of DH on the field [4].

Paper Details

Date Published: 4 March 2019
PDF: 7 pages
Proc. SPIE 10875, Microfluidics, BioMEMS, and Medical Microsystems XVII, 108750U (4 March 2019); doi: 10.1117/12.2509581
Show Author Affiliations
V. Bianco, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
L. Miccio, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
Univ. degli Studi di Napoli Federico II (Italy)
P. Memmolo, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
F. Merola, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
B. Mandracchia, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
T. Cacace, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
M. Mugnano, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
M. Paturzo, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
M. Villone, Univ. degli Studi di Napoli Federico II (Italy)
P. L. Maffettone, Univ. degli Studi di Napoli Federico II (Italy)
P. Ferraro, Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (Italy)
URT-CNR ISSI, NEAPoLIS (Italy)


Published in SPIE Proceedings Vol. 10875:
Microfluidics, BioMEMS, and Medical Microsystems XVII
Bonnie L. Gray; Holger Becker, Editor(s)

© SPIE. Terms of Use
Back to Top