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Effects of high and low level 1265 nm laser irradiation on HCT116 cancer cells
Author(s): Anna Khokhlova; Igor Zolotovskii ; Evgeniia Pogodina; Yury Saenko; Dmitrii Stoliarov; Svetlana Vorsina; Andrei Fotiadi; Daria Liamina; Sergei Sokolovski; Edik Rafailov
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Paper Abstract

The mechanism responsible for the oxidative stress due to photobiomodulation induced by 1265 nm laser is still unclear. Mitochondria are assumed to be the most probable acceptors of the 1265 nm laser irradiation. We study oxidative stress, mitochondrial potential, GSH, cell viability, DNA damage. We demonstrated that narrowband (highcoherent) and wideband lasers employed at the doses of 9.45 and 66.6-400 J/cm2, respectively, induce a dose-dependent cell death, increase ROS level, disturb mitochondrial functioning and can damage DNA. Thus, the 1265 nm lasers can affect the HCT116 cells through mitochondrial damage. Energy density increase contributes to cell damaging without heating effects.

Paper Details

Date Published: 7 March 2019
PDF: 10 pages
Proc. SPIE 10861, Mechanisms of Photobiomodulation Therapy XIV, 108610L (7 March 2019); doi: 10.1117/12.2509529
Show Author Affiliations
Anna Khokhlova, Ulyanovsk State Univ. (Russian Federation)
Igor Zolotovskii , Ulyanovsk State Univ. (Russian Federation)
Evgeniia Pogodina, Ulyanovsk State Univ. (Russian Federation)
Yury Saenko, Ulyanovsk State Univ. (Russian Federation)
Dmitrii Stoliarov, Ulyanovsk State Univ. (Russian Federation)
Svetlana Vorsina, Ulyanovsk State Univ. (Russian Federation)
Andrei Fotiadi, Ulyanovsk State Univ. (Russian Federation)
Aston Univ. (United Kingdom)
Univ. of Mons (United Kingdom)
Daria Liamina, Ulyanovsk State Univ. (Russian Federation)
Sergei Sokolovski, Aston Univ. (United Kingdom)
Edik Rafailov, Aston Univ. (United Kingdom)
Saratov State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 10861:
Mechanisms of Photobiomodulation Therapy XIV
Michael R. Hamblin; James D. Carroll; Praveen Arany, Editor(s)

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