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One-shot Stokes polarimetry for low-cost skin cancer detection
Author(s): Daniel C. Louie; Lioudmila Tchvialeva; Sunil Kalia; Harvey Lui; Tim K. Lee
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Paper Abstract

Introduction: Management of skin cancer worldwide is often a challenge of scale, in that the resources available to detect and treat skin cancer are outweighed by the number of potential cases presented. This project aims to develop oneshot Stokes polarimetry using low-cost components to create a widely available skin cancer detection tool. Methods: A probe was developed to perform one-shot Stokes polarimetry on skin lesions in-vivo. Stokes polarimetry is an optical technique in which a laser of known polarization is fired at a target, and the altered polarization state of the returning light is measured. Typically, measuring a polarization state requires sequential measurements with four polarizing filters, however this probe contains four separate detectors to take these measurements in one shot. This probe was designed to perform at a lower cost and higher speed than traditional polarization methods. The Stokes vector is assessed as opposed to a Mueller matrix image to reduce the number of optical components and measurements required. The probe uses photodiodes and non-actuating film polarizing filters as detectors, and a partially-coherent laser diode as its illumination source. Results: Validation tests of each probe component, and the complete system put together, were performed to confirm the probe’s performance despite its low-cost components. This probe’s potential is demonstrated in a pilot clinical study on 69 skin lesions. The degree of polarization was found to be a factor by which melanoma could be potentially separated from other types of skin lesions.

Paper Details

Date Published: 26 February 2019
PDF: 8 pages
Proc. SPIE 10869, Optics and Biophotonics in Low-Resource Settings V, 1086904 (26 February 2019); doi: 10.1117/12.2509268
Show Author Affiliations
Daniel C. Louie, The Univ. of British Columbia (Canada)
Lioudmila Tchvialeva, The Univ. of British Columbia (Canada)
Sunil Kalia, The Univ. of British Columbia (Canada)
Harvey Lui, The Univ. of British Columbia (Canada)
Tim K. Lee, The Univ. of British Columbia (Canada)

Published in SPIE Proceedings Vol. 10869:
Optics and Biophotonics in Low-Resource Settings V
David Levitz; Aydogan Ozcan, Editor(s)

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