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Multi-spectral fiber spectroscopy methods as solutions for label-free medical diagnostics (Conference Presentation)
Author(s): Olga Bibikova; Ervin Nippolainen; Isaac Afara; Julian Haas; Vesa Virtanen; Lasi Rieppo; Sonata Adomaviciute; Harold Brommer; René van Weeren; Anastasia Melenteva; Valeria Belikova; Urszula Zabarylo; Olaf Minet; Juha Töyräs; Valdas Sablinskas; Boris Mizaikoff; Viacheslav Artyushenko
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Paper Abstract

Optical spectroscopy offers unique opportunities for a label-free investigation of tissues at the molecular level to identify the variety of diseases. To transfer spectroscopic analysis from the scientific laboratories to clinical environment, fiber optic probes are required as optical bridges between the equipment and tissue. We developed single and combined fiber optic probes for the following set of spectroscopy methods: Mid IR-absorption, Raman scattering, Diffuse NIR-reflection, and auto-fluorescence. We benchmarked these methods and selected the optimal one (or their combination), that differentiate between healthy and malignant tissue, based on optical spectra. We tested cancer-normal tissue pairs of human body such as colon, kidney, brain as well as cartilages with and without injuries. Equines cartilage samples with and without osteoarthritis were tested as well. Obtained spectral data were evaluated by multivariate discrimination analysis to enable clear separation of malignant and normal tissues. Data fusion was revealed a synergic effect resulted in increasing of sensitivity, specificity and accuracy (up to 98% for kidney cancer).

Paper Details

Date Published: 4 March 2019
Proc. SPIE 10890, Label-free Biomedical Imaging and Sensing (LBIS) 2019, 108901Q (4 March 2019); doi: 10.1117/12.2509174
Show Author Affiliations
Olga Bibikova, art photonics GmbH (Germany)
Saratov National Research State Univ. (Russian Federation)
Ervin Nippolainen, Univ. of Eastern Finland (Finland)
Isaac Afara, Univ. of Eastern Finland (Finland)
Julian Haas, Univ. Ulm (Germany)
Vesa Virtanen, Univ. of Oulu (Finland)
Lasi Rieppo, Univ. of Oulu (Finland)
Sonata Adomaviciute, Vilnius Univ. (Lithuania)
Harold Brommer, Utrecht Univ. (Netherlands)
René van Weeren, Utrecht Univ. (Netherlands)
Anastasia Melenteva, Samara State Technical Univ. (Russian Federation)
Valeria Belikova, Samara State Technical Univ. (Russian Federation)
Urszula Zabarylo, Charité Universitätsmedizin Berlin (Germany)
Olaf Minet, Charité Universitätsmedizin Berlin (Germany)
Juha Töyräs, Univ. of Eastern Finland (Finland)
Valdas Sablinskas, Vilnius Univ. (Lithuania)
Boris Mizaikoff, Univ. Ulm (Germany)
Viacheslav Artyushenko, art photonics GmbH (Germany)

Published in SPIE Proceedings Vol. 10890:
Label-free Biomedical Imaging and Sensing (LBIS) 2019
Natan T. Shaked; Oliver Hayden, Editor(s)

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