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Direct noninvasive real-time observation of thermoregulation physiology: periodic fluctuations in hematocrit and vascular volume in the peripheral circulation
Author(s): Seth Fillioe; Paul Dent; Bin Deng; Sri Narsipur; Charles M. Peterson; Jerry Goodisman; Richard Steinmann; James Mostrom; J. Chaiken
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Paper Abstract

Thermoregulation is a mammalian physiological function fulfilled in large part by autonomic control of blood flow. We demonstrate the variation in hematocrit (Hct) and intravascular volume (VV) in the peripheral circulation when the external means of maintaining the initial thermal disequilibrium is removed using a PV[O]H device capable of noninvasively measuring both Hct and VV with unprecedented sensitivity, accuracy and precision on a 3 second timescale. Calibrated using an FDA approved device now in standard use for monitoring Hct during dialysis, the PV[O]H detection limit for measuring Hct variation is ±0.03 where 45% is normal. Observing the return to thermal equilibrium at 2 separate anatomic locations, we observe the return to normal homeostasis in a matter of a few minutes. Heat induced vasodilation results in an antecedent increase in plasma volume in greater proportion than for red blood cells into the dilated capillaries. At equilibrium homeostasis i.e. when there is no externally maintained thermal gradient we observe periodic fluctuations in the peripheral Hct and VV on a roughly 15 second to 1.5 minute timescale.

Paper Details

Date Published: 26 February 2019
PDF: 12 pages
Proc. SPIE 10868, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII, 1086803 (26 February 2019); doi: 10.1117/12.2509125
Show Author Affiliations
Seth Fillioe, Syracuse Univ. (United States)
Paul Dent, Syracuse Univ. (United States)
Bin Deng, Syracuse Univ. (United States)
Sri Narsipur, SUNY Upstate Medical Univ. (United States)
Charles M. Peterson, Syracuse Univ. (United States)
Jerry Goodisman, Syracuse Univ. (United States)
Richard Steinmann, Crouse Health (United States)
James Mostrom, Crouse Health (United States)
J. Chaiken, Syracuse Univ. (United States)

Published in SPIE Proceedings Vol. 10868:
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII
Anita Mahadevan-Jansen, Editor(s)

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