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Time-reversed ultrasonically encoded (TRUE) optical focusing through highly scattering ex vivo human cataractous lenses for congenital cataract treatment (Conference Presentation)

Paper Abstract

Normal development of the visual system in infants relies on clear images being projected onto the retina, which can be disrupted by lens opacity caused by congenital cataract. This disruption, if uncorrected in early life, results in amblyopia (permanently decreased vision even after removal of the cataract). Doctors are able to prevent amblyopia by removing the cataract during the first several weeks of life, but this surgery risks a host of complications which can be equally visually disabling. Here, we investigated the feasibility of focusing light noninvasively through highly scattering cataractous lenses to stimulate the retina, thereby preventing amblyopia. This approach would allow the cataractous lens removal surgery to be delayed and hence greatly reduce the risk of complications from early surgery. Employing a wavefront shaping technique named time-reversed ultrasonically encoded (TRUE) optical focusing in reflection mode, we focused 532 nm light through a highly scattering ex vivo adult human cataractous lens of 112 mean free path thick. This work demonstrates a potential clinical application of wavefront shaping techniques.

Paper Details

Date Published: 4 March 2019
Proc. SPIE 10886, Adaptive Optics and Wavefront Control for Biological Systems V, 1088602 (4 March 2019); doi: 10.1117/12.2508994
Show Author Affiliations
Yan Liu, Caltech (United States)
Yuecheng Shen, Caltech (United States)
Haowen Ruan, Caltech (United States)
Frank L. Brodie, Univ. of California, San Francisco (United States)
Terence T. W. Wong, Caltech (United States)
Changhuei Yang, Caltech (United States)
Lihong V. Wang, Caltech (United States)

Published in SPIE Proceedings Vol. 10886:
Adaptive Optics and Wavefront Control for Biological Systems V
Thomas G. Bifano; Sylvain Gigan; Na Ji, Editor(s)

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