Share Email Print

Proceedings Paper • new

Optimization of uptake and transport of gold nanoparticles in two-dimensional and three-dimensional in-vitro cell models
Author(s): Kyle Bromma; Leah Cicon; Aaron Bannister; Kristy Rieck; Wayne Beckham; B. D. Chithrani
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

High atomic number nanomaterials have been explored as a tool for improving cancer therapeutics. Gold nanoparticles are a system that has been introduced as they can act as effective radiation dose enhancers and anticancer drug carries. Gold nanoparticles have unique physiochemical properties that allow them to be probed in cells using techniques such as scanning electron microscopy and hyper spectral imaging. Optimization of gold nanoparticle uptake into 3D in-vitro models is essential to optimizing future cancer therapeutic applications and bridging the gap between in-vitro and in-vivo tumor environments. The uptake of functionalized gold nanoparticles into 2D monolayer and 3D spheroid cell models was tested. Functionalization of the GNPs was confirmed by use of dynamic light scattering, UV-Visible light spectroscopy, the Zeta potential, and imaged with a scanning electron microscope and hyper spectral imaging. These findings suggest that both the size and functionalization of the gold nanoparticles should be considered in future 3D in-vitro studies.

Paper Details

Date Published: 7 March 2019
PDF: 9 pages
Proc. SPIE 10892, Colloidal Nanoparticles for Biomedical Applications XIV, 108920U (7 March 2019); doi: 10.1117/12.2508934
Show Author Affiliations
Kyle Bromma, Univ. of Victoria (Canada)
Leah Cicon, Univ. of Victoria (Canada)
Aaron Bannister, Univ. of Victoria (Canada)
Kristy Rieck, Univ. of Victoria (Canada)
Wayne Beckham, Univ. of Victoria (Canada)
BC Cancer Agency (Canada)
B. D. Chithrani, Univ. of Victoria (Canada)
BC Cancer Agency (Canada)

Published in SPIE Proceedings Vol. 10892:
Colloidal Nanoparticles for Biomedical Applications XIV
Marek Osiński; Wolfgang J. Parak, Editor(s)

© SPIE. Terms of Use
Back to Top