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Multi-wavelength time domain diffuse optical tomography for breast cancer: initial results on silicone phantoms
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Paper Abstract

Time domain Diffuse Optical Tomography (TD-DOT) non-invasively probes the optical proprieties of biological tissue. These can be related to changes in tissue composition, thus making TD-DOT potentially valuable for cancer imaging. In particular, an application of interest is therapy monitoring for breast cancer. Thus, we developed a software tool for multiwavelength TD-DOT in reflectance geometry. While the use of multiple wavelengths probes the main components of the breast, the chosen geometry offers the advantage of linking the photon flight time to the investigated depth. We validated the tool on silicon phantoms embedding an absorbing inclusion to simulate a malignant lesion in breast tissue. Also, we exploited the a priori information on position and geometry of the inclusion by using a morphological prior constraint. The results show a good localization of the depth of inclusion but a reduced quantification. When the morphological constraint is used, though, the localization improves dramatically, also reducing surface artifacts and improving quantification as well. Still, there is room for improvement in the quantification of the “lesion” properties.

Paper Details

Date Published: 1 March 2019
PDF: 6 pages
Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108741N (1 March 2019); doi: 10.1117/12.2508657
Show Author Affiliations
Edoardo Ferocino, Politecnico di Milano (Italy)
Giuseppe Di Sciacca, Univ. College London (United Kingdom)
Laura Di Sieno, Politecnico di Milano (Italy)
Alberto Dalla Mora, Politecnico di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
Simon Arridge, Univ. College London (United Kingdom)
Fabrizio Martelli, Univ. degli Studi di Firenze (Italy)
Paola Taroni, Politecnico di Milano (Italy)
Andrea Farina, CNR-Istituto di Fotonica e Nanotecnologie (Italy)


Published in SPIE Proceedings Vol. 10874:
Optical Tomography and Spectroscopy of Tissue XIII
Sergio Fantini; Bruce J. Tromberg; Eva Marie Sevick-Muraca; Paola Taroni, Editor(s)

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