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A novel fluorescent gold nanoparticle inhibiting migration and invasion of tumor cells
Author(s): Jianpeng Xue; Zeqing Li; Hanmei Xu; Yang Pu
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Paper Abstract

Matrix metalloproteinases (MMPs) plays an important role in the regulation of invasion and metastasis of tumor cells. In this work, an inhibitory peptide of MMP-2 and MMP-9 was conjugated to gold nanoparticle as an inhibitor to MMP-2 and MMP-9 to improve chemical and physical stability. The results were proved that this nanoparticle showed inhibition on the enzymatic activity of MMP-2 and MMP-9, and significantly inhibited the migration and invasion of tumor cells in vitro. This gold nanoparticle can be functioned as an inhibitor with a more pronounced inhibitory effect on invasion and metastasis of tumor.

Paper Details

Date Published: 7 March 2019
PDF: 6 pages
Proc. SPIE 10893, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XI, 108930S (7 March 2019); doi: 10.1117/12.2508636
Show Author Affiliations
Jianpeng Xue, China Pharmaceutical Univ. (China)
Zeqing Li, China Pharmaceutical Univ. (China)
Hanmei Xu, China Pharmaceutical Univ. (China)
Yang Pu, MicroPhotoAcoustics, Inc. (United States)


Published in SPIE Proceedings Vol. 10893:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XI
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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