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Model of malignant breast biopsies and predictions of their WAXS energy integrated signals
Author(s): R. J. LeClair; M. Brunet
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Paper Abstract

A numerical study of the wide angle x-ray scatter (WAXS) energy integrated signals (EISs) from breast biopsies was conducted. A benign biopsy was chosen as fibroglandular (fib) tissue whereas biopsies with cancer were approximated as consisting of fib tissue and a cluster of epithelial cells. The grouping of cells represented the malignant portion. The EISs due to scatter were computed for biopsies of thickness dbio = 2 mm, 5 mm, 10 mm and 20 mm. For the malignant biopsies, the fractional volumes of cells (νcell) studied ranged from 0.01 to 0.1. Incident 2 mm diam beams of 30 kV, 50 kV, 80 kV, and 140 kV were considered. The tube current and exposure time were 3 mA and 1 minute, respectively. The WAXS signals were computed by adding the signals from annular detectors subtending scattering angles θ = 2°, 3°, , 23° and solid angles Ωθ = 2.0 x π x [cos(θ - ∆θ/2) - cos(θ + ∆θ/2)] x cos θ where ∆θ = 1°. Let the EIS due to a malignant biopsy be EISms and that of a benign one, EISbs. With these signals, values of SNR were computed. The 30 kV beam provided SNRs < 5 for the lowest entrance exposure, X = 0.0015 C/kg. For biopsies with dbio = 2, 5, 10, 20 mm and νcell = 0.1, the SNRs were 28.0, 38.2, 43.0, and 40.0. The findings suggest that there is potential to use WAXS EISs to diagnose malignancy in breast biopsies.

Paper Details

Date Published: 1 March 2019
PDF: 8 pages
Proc. SPIE 10948, Medical Imaging 2019: Physics of Medical Imaging, 1094803 (1 March 2019); doi: 10.1117/12.2508379
Show Author Affiliations
R. J. LeClair, Laurentian Univ. (Canada)
M. Brunet, Laurentian Univ. (Canada)


Published in SPIE Proceedings Vol. 10948:
Medical Imaging 2019: Physics of Medical Imaging
Taly Gilat Schmidt; Guang-Hong Chen; Hilde Bosmans, Editor(s)

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