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Novel promising stroke therapy: new pharmacological and laser stimulation of brain clearance
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Paper Abstract

Stroke and traumatic brain injury are often associated with formation of brain edema, which is a potentially fatal pathological state provoking extensive accumulation of fluid in the brain tissues resulting in elevation of intracranial pressure and leading to impaired nerve function. There is only symptomatic anti-edema therapy is currently available. Therefore, the development of novel strategies to remove edema fluid is required. The brain edema is classified as vasogenic or cytotoxic edema, which associated with excess accumulation of fluid (edema) around capillaries resulting from disruption of the blood-brain barrier (BBB) or intracellular spaces (cell swelling) of the brain, respectively. In this brief review, we discuss possible mechanisms underlying brain edema formation and new strategies in development of novel of anti-edema drugs.

Paper Details

Date Published: 4 March 2019
PDF: 6 pages
Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 108790C (4 March 2019); doi: 10.1117/12.2508259
Show Author Affiliations
O. Semyachkina-Glushkovskaya, Saratov State Univ. (Russian Federation)
M. Klimova, Saratov State Univ. (Russian Federation)
E. Duarte Torres, Saratov State Univ. (Russian Federation)
A. Khorovodov, Saratov State Univ. (Russian Federation)
A. Terskov, Saratov State Univ. (Russian Federation)
A. Mamedova, Saratov State Univ. (Russian Federation)
A. E. Shareef, Saratov State Univ. (Russian Federation)
E. Saranceva, Saratov State Univ. (Russian Federation)
T. Iskra, Saratov State Univ. (Russian Federation)
A. Pavlov, Saratov State Univ. (Russian Federation)
Yuri Gagarin State Technical Univ. of Saratov (Russian Federation)
J. Kurths, Saratov State Univ. (Russian Federation)
Potsdam Institute for Climate Impact Research (Germany)
Humboldt Univ. Berlin (Germany)


Published in SPIE Proceedings Vol. 10879:
Biophotonics and Immune Responses XIV
Wei R. Chen, Editor(s)

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