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Fluorescence molecular tomography based on L2,1-norm method for morphological reconstruction
Author(s): Shixin Jiang; Jie Liu; Yu An; Yuan Gao; Kun Wang; Jie Tian
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Paper Abstract

With the development of fluorescence molecular tomography (FMT), it has become an important tool for life science research. Many methods were developed to improve the reconstruction performance of FMT. However, these methods only focus on the accuracy and speed of the reconstruction, while ignoring the morphological information of the tumor. In this paper, the modified L2,1-norm method were adopted to reconstruct the morphology of the mouse orthotopic glioma. To verify the L2,1-norm method, we carried out the simulation experiment and the in vivo orthotopic glioma mouse experiment. The iterated shrinkage (IS) method and the Tikhonov-based method were implemented for comparison. The results show that the modified L2,1-norm method can obtain more accurate reconstruction in both tumor location and morphology reconstruction. We believe that the morphological reconstruction of FMT will provide more potential for preclinical research.

Paper Details

Date Published: 4 March 2019
PDF: 7 pages
Proc. SPIE 10881, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVII, 108810I (4 March 2019); doi: 10.1117/12.2508235
Show Author Affiliations
Shixin Jiang, Beijing Jiaotong Univ. (China)
Institute of Automation (China)
Jie Liu, Beijing Jiaotong Univ. (China)
Yu An, Institute of Automation (China)
Yuan Gao, Institute of Automation (China)
Kun Wang, Institute of Automation (China)
Jie Tian, Institute of Automation (China)
Beihang Univ. (China)

Published in SPIE Proceedings Vol. 10881:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVII
Daniel L. Farkas; Attila Tárnok; James F. Leary, Editor(s)

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