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Temperature near-infrared absorption spectrum monitoring for in vivo tissue based on a new scattering-independent measurement
Author(s): Jin Liu; Lingxing Guo; Xueyu Liu; Tongshuai Han; Kexin Xu
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Paper Abstract

We present a scattering-independent measurement to monitor the pure near-infrared light absorption variation for scattering media, especially for in vivo tissue. We found a scattering variation independent source-detector separation (SVI-SDS), where the diffuse light intensity only varies with tissue absorption change but does not vary with scattering change. We applied the SVI-SDS setup to monitor the tissue spectra with a temperature modulation. We also proposed a method to simplify the measurement by using two fixed SDSs for all wavelengths. It makes the detection device easy to design and fit to the required SVI-SDSs. Monte Carlo simulation and experiments on intralipid solutions and in vitro pig skin samples are performed to test the method. The temperature absorption spectra were acquired, and the temperature insensitive wavelengths of the tissue are discussed. We believe this new method will guide many potential applications for the absorption-based tissue spectroscopy.

Paper Details

Date Published: 20 February 2019
PDF: 9 pages
Proc. SPIE 10885, Optical Diagnostics and Sensing XIX: Toward Point-of-Care Diagnostics, 108850X (20 February 2019); doi: 10.1117/12.2508111
Show Author Affiliations
Jin Liu, Tianjin Univ. (China)
Lingxing Guo, Tianjin Univ. (China)
Xueyu Liu, Tianjin Univ. (China)
Tongshuai Han, Tianjin Univ. (China)
Kexin Xu, Tianjin Univ. (China)


Published in SPIE Proceedings Vol. 10885:
Optical Diagnostics and Sensing XIX: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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