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Comparing the efficacy and safety of infrared neural stimulation at 1450nm and 1875nm (Conference Presentation)
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Paper Abstract

Infrared neural stimulation (INS) is a promising neuromodulation technique capable of exciting neural tissue without the need for exogeneous agents or genetic modification. Due to its high spatial specificity, INS could improve upon traditional methods of selective neural stimulation in both the laboratory and the clinic. As of yet, no study has compared the efficacy and safety of using different INS parameters such as spot size and wavelength. Moreover, differences in the methods of determining energy deposition and laser spot size make it difficult to compare stimulation parameters used in the current literature. Here, we present results comparing INS efficacy using 1450nm and 1875nm light over a range of spot sizes and radiant exposures. Stimulation thresholds were determined using recorded compound muscle action potentials (CMAPs) and visible muscle contractions in an in vivo rat sciatic nerve model. Overall, 1450nm light required lower radiant exposures to achieve threshold activation as compared to 1875nm. While radiant exposures remained relatively constant across different spot sizes when using 1450nm, the threshold radiant exposures for 1875nm exposures increased with spot size suggesting deeper nerves fibers tend to be activated. Moreover, exposures using a flat-top beam profile yielded less variability in the stimulation threshold than those using a Gaussian profile. As in previous studies, histology confirmed that damaging radiant exposures are several times greater than the stimulation threshold for both 1450nm and 1875nm. Our results provide valuable insight for future studies involving INS and for further developing INS as both a research and clinical tool.

Paper Details

Date Published: 7 March 2019
Proc. SPIE 10866, Optogenetics and Optical Manipulation 2019, 108660G (7 March 2019); doi: 10.1117/12.2508055
Show Author Affiliations
Graham Throckmorton, Vanderbilt Univ. (United States)
Wilson R. Adams, Vanderbilt Univ. (United States)
Zane Ricks, Vanderbilt Univ. (United States)
Jonathan Cayce, Vanderbilt Univ. (United States)
E. Duco Jansen, Vanderbilt Univ. (United States)
Anita Mahadevan-Jansen, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 10866:
Optogenetics and Optical Manipulation 2019
Samarendra K. Mohanty; E. Duco Jansen, Editor(s)

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