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DNA based molecular logic devices: a review of some ongoing work with multifluorophore FRET systems
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Paper Abstract

The development of dynamic DNA nanostructures has opened the door to a wide variety of applications including sensing and information processing. DNA based molecular logic devices (MLDs) are DNA structures that have the ability to sense multiple inputs or “targets”, autonomously process the absence or presence of targets, and provide an output signal indicating the logic state of the system. As DNA is readily functionalized with fluorescent molecules, fluorophores can be strategically placed on MLDs so that the Förster resonance energy transfer efficiencies between the fluorophores are modulated when the DNA structure undergoes rearrangement. Consequently, the fluorescent signal of the dyes can be used as an output that provides the current logic state of the system. Although still in their elementary phase, MLDs have proved to be a promising modality for sensing multiple nanoscale targets, especially nucleic acids. Here, we review the development of multifluorophore MLDs and utilize examples from the literature and our own work to highlight their potential capabilities.

Paper Details

Date Published: 7 March 2019
PDF: 8 pages
Proc. SPIE 10894, Plasmonics in Biology and Medicine XVI, 1089416 (7 March 2019); doi: 10.1117/12.2508054
Show Author Affiliations
David A. Hastman Jr., U.S. Naval Research Lab. (United States)
Univ. of Maryland (United States)
Sebastián A. Díaz, U.S. Naval Research Lab. (United States)
Igor L. Medintz, U.S. Naval Research Lab. (United States)


Published in SPIE Proceedings Vol. 10894:
Plasmonics in Biology and Medicine XVI
Tuan Vo-Dinh; Ho-Pui A. Ho; Krishanu Ray, Editor(s)

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