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Polydimethylsiloxane eye phantoms to mimic human eye for evaluating intraocular pressure (Conference Presentation)
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Paper Abstract

Intraocular pressure is very significant in ophthalmology and it is used to diagnose glaucoma. It is usually estimated by a tonometer based on the Imbert-Fick law. However, systematic investigation for the effect of the geometrical and mechanical characteristics of eye phantom on the validity of the tonometer pressure is rare. We fabricated polydimethylsiloxane eye phantoms of which 3-D geometries based on Archimedes principle and mechanical properties were tailored to those properties of human eye and applied to evaluate the validity of tonometer pressure. The shell thickness at the center as well as the mechanical modulus was controlled by the concentration of ethylene glycol and the formulation of PDMS, respectively. Optical coherence tomography and tonometer were used to determine the detailed geometrical information of eye phantom and tonometer pressure, respectively. The thickness of the shell at the centre of eye phantom could be varied from 0.2 mm to 1.0 mm with different modulus. The range of eye phantom properties is comparable to the typical values of the modulus and the thickness of human eye of 0.4 MPa and 0.52 mm, respectively. The tonometer pressure was found to be dependent on the shell thickness as well as the modulus of the shell. We have successfully developed eye phantoms for evaluating the validity of tonometer pressure. The values measured from eye phantoms are similar to the typical IOP of human eye if the modulus and thickness of the shell are similar to those of human eye.

Paper Details

Date Published: 4 March 2019
Proc. SPIE 10870, Design and Quality for Biomedical Technologies XII, 108700T (4 March 2019); doi: 10.1117/12.2507752
Show Author Affiliations
Han Saem Cho, Korea Research Institute of Standards and Science (Korea, Republic of)
Seung Hyen Lee, Bundang Jesaeng General Hospital (Korea, Republic of)
Heung Soon Lee, Korea Research Institute of Standards and Science (Korea, Republic of)
Heh Young Moon, Gachon Univ. (Korea, Republic of)
Sae Chae Jung, KRISS (Kosovo, Republic of)

Published in SPIE Proceedings Vol. 10870:
Design and Quality for Biomedical Technologies XII
Rongguang Liang; Jeeseong Hwang, Editor(s)

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