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Water and lipid contents measured at various parts of the human body with a six-wavelength time-resolved spectroscopy system
Author(s): Hiroaki Suzuki; Etsuko Ohmae; Kenji Yoshimoto; Hiroko Wada; Shu Homma; Norihiro Suzuki; Tetsuya Mimura; Yutaka Yamashita; Yukio Ueda
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Paper Abstract

Time-domain (TD) near-infrared spectroscopy (NIRS) is an effective method of quantifying optical and biological properties, such as the mean optical path length, absorption coefficient, reduced scattering coefficient, and oxyhemoglobin and deoxy-hemoglobin concentrations of biological tissues. In addition to these parameters, water and lipid contents are important biological parameters expected to be useful information in clinical application. For our previous TD-NIRS systems, we used three wavelengths (760, 800, and 830 nm) that are sensitive to oxy- and deoxy-hemoglobin. To quantitatively measure water and lipid contents of biological tissues, we developed a new TD-NIRS system with three additional wavelengths (908, 936, and 976 nm) that are sensitive to water and lipids. The new six-wavelength TDNIRS system comprises six-wavelength pulsed light sources, two types of photomultiplier tubes (GaAs and InGaAs PMTs), a time-correlated single-photon counting unit, and optical fiber bundles. In this pilot study, we present the measurement results of oxy- and deoxy-hemoglobin concentrations, tissue oxygen saturation, and water and lipid contents at the calf, forearm, and abdomen of five healthy adult volunteers in a resting state using the six-wavelength TD-NIRS system. We thus confirmed that the fat thickness measured by ultrasonography and the water content measured by the six-wavelength TD-NIRS system were negatively correlated, whereas the fat thickness and lipid content were positively correlated. We expect that the six-wavelength TD-NIRS system will be used in clinical studies as a point-of-care testing device for the bedside monitoring of human subjects.

Paper Details

Date Published: 1 March 2019
PDF: 6 pages
Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108740A (1 March 2019); doi: 10.1117/12.2507429
Show Author Affiliations
Hiroaki Suzuki, Hamamatsu Photonics K.K. (Japan)
Etsuko Ohmae, Hamamatsu Photonics K.K. (Japan)
Kenji Yoshimoto, Hamamatsu Photonics K.K. (Japan)
Hiroko Wada, Hamamatsu Photonics K.K. (Japan)
Shu Homma, Hamamatsu Photonics K.K. (Japan)
Norihiro Suzuki, Hamamatsu Photonics K.K. (Japan)
Tetsuya Mimura, Hamamatsu Photonics K.K. (Japan)
Yutaka Yamashita, Hamamatsu Photonics K.K. (Japan)
Yukio Ueda, Hamamatsu Photonics K.K. (Japan)

Published in SPIE Proceedings Vol. 10874:
Optical Tomography and Spectroscopy of Tissue XIII
Sergio Fantini; Bruce J. Tromberg; Eva Marie Sevick-Muraca; Paola Taroni, Editor(s)

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