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Investigation of oxazine and rhodamine derivatives as peripheral Nerve tissue targeting contrast agent for in vivo fluorescence imaging
Author(s): Lei G. Wang; Connor W. Barth; Jason R. Combs; Antonio R. Montaño; Summer L. Gibbs
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Paper Abstract

Accidental nerve transection or injury is a significant morbidity associated with many surgical interventions, resulting in persistent postsurgical numbness, chronic pain, and/or paralysis. Nervesparing can be a difficult task due to patient-to-patient variability and the difficulty of nerve visualization in the operating room. Fluorescence image-guided surgery to aid in the precise visualization of vital nerve structures in real time during surgery could greatly improve patient outcomes. To date, all nerve-specific contrast agents emit in the visible range. Developing a nearinfrared (NIR) nerve-specific fluorophore is poised to be a challenging task, as a NIR fluorophore must have enough “double-bonds” to reach the NIR imaging window, contradicting the requirement that a nerve-specific agent must have a relatively low molecular weight to cross the blood-nervebarrier (BNB). Herein we report our efforts to investigate the molecular characteristics for the nervespecific oxazine fluorophores, as well as their structurally analogous rhodamine fluorophores. Specifically, optical properties, physicochemical properties and their in vivo nerve specificity were evaluated herein.

Paper Details

Date Published: 7 March 2019
PDF: 11 pages
Proc. SPIE 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, 108620H (7 March 2019); doi: 10.1117/12.2507296
Show Author Affiliations
Lei G. Wang, Oregon Health & Science Univ. (United States)
Connor W. Barth, Oregon Health & Science Univ. (United States)
Jason R. Combs, Oregon Health & Science Univ. (United States)
Antonio R. Montaño, Oregon Health & Science Univ. (United States)
Summer L. Gibbs, Oregon Health & Science Univ. (United States)

Published in SPIE Proceedings Vol. 10862:
Molecular-Guided Surgery: Molecules, Devices, and Applications V
Brian W. Pogue; Sylvain Gioux, Editor(s)

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