Share Email Print
cover

Proceedings Paper • new

Phototoxicity and luminescence of the upconversion nanoparticles embedded in the cells
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

The present work demonstrates the visualization of the intracellular distribution of upconversion nanoparticles (UCNPs) by microscopy with excitation in the NIR spectral range and detection of upconversion luminescence in the VIS range. The cell viability is scored for cytotoxic effects of UCNPs at dark and light exposed conditions. Non-functionalized UCNPs incubated with the cells are found to be endocytosed by cells. The obtained results confirm a high sensitivity of the luminescent UCNPs to the concentration variations within cells. UCNPs are promising alternatives to traditional fluorescent labels for cell imaging and possess prominent potentials in biological and clinical applications.

Paper Details

Date Published: 1 March 2019
PDF: 6 pages
Proc. SPIE 10877, Dynamics and Fluctuations in Biomedical Photonics XVI, 108770Y (1 March 2019); doi: 10.1117/12.2506974
Show Author Affiliations
I. Yu. Yanina, Saratov State Univ. (Russian Federation)
Tomsk State Univ. (Russian Federation)
E. A. Sagaidachnaya, Saratov State Univ. (Russian Federation)
I. V. Vidyasheva, Saratov State Univ. (Russian Federation)
N. A. Navolokin, Saratov State Medical Univ. (Russian Federation)
V. I. Kochubey, Saratov State Univ. (Russian Federation)
Tomsk State Univ. (Russian Federation)
V. V. Tuchin, Saratov State Univ. (Russian Federation)
Tomsk State Univ. (Russian Federation)
Institute of Precision Mechanics and Control (Russian Federation)


Published in SPIE Proceedings Vol. 10877:
Dynamics and Fluctuations in Biomedical Photonics XVI
Valery V. Tuchin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

© SPIE. Terms of Use
Back to Top