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Focused x-ray luminescence computed tomography: experimental studies
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Paper Abstract

X-ray luminescence computed tomography (XLCT) is an emerging hybrid molecular imaging modality with great promises in overcoming the strong optical scattering in deep tissues for good spatial resolution. Though the narrow x-ray beam XLCT imaging has been demonstrated to obtain high spatial resolution at depth, it suffers from a relatively long measurement time, hindering its practical applications. Recently, we have designed a focused x-ray beam based XLCT imaging system and have successfully performed imaging in about 12.5 minutes per section imaging for a mouse sized object. Following this previous work, in this current study, we have performed XLCT imaging using our focused x-ray beam for both a tissue-mimicking phantom and for the first time, with a euthanized mouse embedded with a capillary tube target filled with 10.0 mg/mL of GOS:Eu3+ microphosphors and have shown that the data acquisition time could be reduced substantially to less than 10 milliseconds per linear scan step compared to the previous study which used 1 second per linear step. In addition, the targets were reconstructed with a high location accuracy and good shape. In the current setup, the total measurement time for a mouse sized object could be reduced to about 7.5 seconds per section imaging, a major improvement from previous studies.

Paper Details

Date Published: 27 February 2019
PDF: 9 pages
Proc. SPIE 10871, Multimodal Biomedical Imaging XIV, 108710G (27 February 2019); doi: 10.1117/12.2506927
Show Author Affiliations
Michael C. Lun, Univ. of California, Merced (United States)
Wei Zhang, Peking Union Medical College (China)
Changqing Li, Univ. of California, Merced (United States)

Published in SPIE Proceedings Vol. 10871:
Multimodal Biomedical Imaging XIV
Fred S. Azar; Xavier Intes; Qianqian Fang, Editor(s)

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