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Treatment of pancreatic tumors using combination of laser irradiation and immunological stimulation (Conference Presentation)
Author(s): Wei R. Chen; Jingxuan Yang; Min Li; Feifan Zhou; Meng Wang
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Paper Abstract

Pancreatic cancer is one of the most challenging diseases. Patients with metastatic pancreatic cancer has a poor prognosis with a 3% five-year survival rate. The high mortality rate is largely due to two major factors: the severely limited resectability and extremely high rate of metastasis. We applied laser immunotherapy (LIT) to treat a highly metastatic, poorly immunogenic pancreatic tumor model (Panc02-H7) in mice. Subcutaneous tumors were irradiated by a near-infrared laser non-invasively and orthotopic tumors were irradiated by the laser interstitially, followed by intratumoral injection of glycated chitosan, an immunoadjuvant. Long-term survival and tumor-specific immunity were observed after LIT treatment. The effectiveness of LIT in treating pancreatic tumors demonstrated in this study could lead to a feasible modality for this deadly disease.

Paper Details

Date Published: 7 March 2019
Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 1087907 (7 March 2019); doi: 10.1117/12.2506731
Show Author Affiliations
Wei R. Chen, Univ. of Central Oklahoma (United States)
Jingxuan Yang, The Univ. of Oklahoma Health Sciences Ctr. (United States)
Min Li, The Univ. of Oklahoma Health Sciences Ctr. (United States)
Feifan Zhou, Shenzhen Univ. (China)
Meng Wang, Shenzhen Univ. (China)

Published in SPIE Proceedings Vol. 10879:
Biophotonics and Immune Responses XIV
Wei R. Chen, Editor(s)

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