Share Email Print

Proceedings Paper • new

Spectral contrast optical coherence tomography angiography (Conference Presentation)
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

A new method is presented, called Spectral Contrast Optical Coherence Tomography, which utilizes the visible spectrum of blood instead of doppler or speckle contrast to locate blood vessels. This is seen as a significant improvement for OCT angiography, since sample motion no longer affects vessel contrast, repetitive scanning is not required, and non-flowing blood can be imaged. A visible Optical Coherence Tomography system from 500-700 nm was used and the differential spectral intensity of two short time Fourier Transform Kaiser sampling windows centered at 557 nm and 620 nm provided contrast revealing blood vessel location. This approach allows for single-scan endogenous contrast angiography all the way down to the capillary level. We demonstrate the method by imaging the vasculature of human oral mucosa and the lymphatics and vasculature of freshly sacrificed mouse tissue.

Paper Details

Date Published: 4 March 2019
Proc. SPIE 10867, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, 108671H (4 March 2019); doi: 10.1117/12.2506664
Show Author Affiliations
James A. Winkelmann, Northwestern Univ. (United States)
Graham Spicer, Northwestern Univ. (United States)
Aya Eid, Northwestern Univ. (United States)
Quyen Nguyen, Northwestern Univ. (United States)
Vadim Backman, Northwestern Univ. (United States)

Published in SPIE Proceedings Vol. 10867:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII
James G. Fujimoto; Joseph A. Izatt, Editor(s)

© SPIE. Terms of Use
Back to Top