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BSA-modified gold nanorods for combined photothermal therapy and immunotherapy of melanoma
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Paper Abstract

Nanoparticle-based combination therapy may provide an effective therapeutic strategy. Herein, we show that bovine serum albumin (BSA)-bioinspired gold nanorods (GNRs) loaded with immunoadjuvant for combined photothermal therapy (PTT) and immunotherapy for treatment of melanoma. In this work, cetyltrimethylammonium bromide (CTAB) coated GNRs were successively decorated with polyethylene glycol (PEG) and BSA, and loaded with an immunoadjuvant imiquimod (R837). The synthesized mPEGGNRs@ BSA/R837 nanocomplexes could significantly induce immune response in vitro. Furthermore, under near-infrared (NIR) irradiation could effectively kill tumor cells. The nanocomplex-based PTT in combination with immunotherapy may be potentially employed as an effective strategy for the treatment of melanoma and other metastatic cancers.

Paper Details

Date Published: 7 March 2019
PDF: 8 pages
Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 108790N (7 March 2019); doi: 10.1117/12.2506097
Show Author Affiliations
Benqing Zhou, Shenzhen Univ. (China)
Meng Wang, Shenzhen Univ. (China)
Feifan Zhou, Shenzhen Univ. (China)
Jun Song, Shenzhen Univ. (China)
Junle Qu, Shenzhen Univ. (China)
Wei R. Chen, Univ. of Central Oklahoma (United States)

Published in SPIE Proceedings Vol. 10879:
Biophotonics and Immune Responses XIV
Wei R. Chen, Editor(s)

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