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Identification of specific histological characteristics of glioblastoma based on multiphoton microscopy
Author(s): Zhida Chen; Xiaomin Huang; Xingfu Wang; Deyong Kang; Yuanxiang Lin; Zanyi Wu; Shu Wang; Na Fang; Jianxin Chen
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Paper Abstract

Glioblastoma (GBM) is a highly malignant and rapidly invasive astrocytoma, which has explosive biologic properties with rapid clinical progression leading to death and has a poor clinical outcome. The average survival time of most patients is only 12 to 15 months. GBM is distinguished pathologically from lower grade tumors by ‘pseudopalisading’ necrosis and microvascular hyperplasia. The most exaggerated form of microvascular hyperplasia is called glomeruloid body. MPM is a potential tool for imaging biological tissues at the molecular level. In this paper, MPM based on twophoton excited fluorescence (TPEF) and second harmonic generation (SHG) was applied for identifying the GBM without labeling or fluorescent markers. The results showed that MPM can display the specific histological characteristics of GBM including ‘pseudopalisading’ necrosis and glomeruloid vascular proliferation. The results obtained are consistent with the diagnosis of pathological findings. MPM will become a promising imaging tool for preoperative diagnosis of glioblastoma in the future.

Paper Details

Date Published: 15 November 2018
PDF: 4 pages
Proc. SPIE 10964, Tenth International Conference on Information Optics and Photonics, 109643G (15 November 2018); doi: 10.1117/12.2505946
Show Author Affiliations
Zhida Chen, Fujian Normal Univ. (China)
Xiaomin Huang, Fujian Normal Univ. (China)
Xingfu Wang, Fujian Medical Univ. (China)
Deyong Kang, Fujian Medical Univ. (China)
Yuanxiang Lin, Fujian Medical Univ. (China)
Zanyi Wu, Fujian Medical Univ. (China)
Shu Wang, Fujian Normal Univ. (China)
Na Fang, Fujian Normal Univ. (China)
Jianxin Chen, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 10964:
Tenth International Conference on Information Optics and Photonics
Yue Yang, Editor(s)

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