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Analysis of small vessel cochlear blood flow regulation during loud sound exposure in the mouse
Author(s): George W. S. Burwood; Suzan Dziennis; Teresa Wilson; Jianlong Yang; Gangjun Liu; Sarah Foster; Ruikang Wang; Alfred L. Nuttall
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Paper Abstract

Using optical coherence tomography angiography, we measured blood flow from the vessels in the lateral wall in the mouse cochlea directly through bone in mice with and without sympathetic neuronal function. We present in vivo imaging of blood flow and mechanical vibration in mice subjected to 30 min of loud sound. Loud sound caused blood flow reduction. In mice with superior cervical ganglion ablation, the loud sound-induced reduction in blood flow was partially ameliorated. These results demonstrate that sympathetic innervation likely plays a role in the pathological decrease in blood flow observed in the lateral wall vessels in response to loud sound.

Paper Details

Date Published: 15 November 2018
PDF: 5 pages
Proc. SPIE 10964, Tenth International Conference on Information Optics and Photonics, 109641R (15 November 2018); doi: 10.1117/12.2505434
Show Author Affiliations
George W. S. Burwood, Oregon Health & Science Univ. (United States)
Suzan Dziennis, Oregon Health & Science Univ. (United States)
Teresa Wilson, Oregon Health & Science Univ. (United States)
Jianlong Yang, Oregon Health & Science Univ. (United States)
Gangjun Liu, Oregon Health & Science Univ. (United States)
Sarah Foster, Oregon Health & Science Univ. (United States)
Ruikang Wang, Univ. of Washington (United States)
Alfred L. Nuttall, Oregon Health & Science Univ. (United States)


Published in SPIE Proceedings Vol. 10964:
Tenth International Conference on Information Optics and Photonics
Yue Yang, Editor(s)

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