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High-resolution chromophore concentration recovery using multi-wavelength photo-magnetic imaging
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Paper Abstract

Although diffuse optical tomography (DOT) is able to obtain valuable functional information, its routine use in clinic is hampered by its poor spatial resolution and quantitative accuracy. Previously, our team introduced Photo-Magnetic Imaging (PMI) to overcome the limitation of DOT. PMI is a hybrid modality that synergistically utilizes optics and Magnetic Resonance Imaging (MRI). While illuminating the imaged medium by near-infrared laser, the induced internal temperature increase is measured using Magnetic Resonance Thermometry (MRT). Using these MRT maps, optical absorption maps at the laser's wavelength can be recovered using the dedicated PMI image reconstruction algorithm. In this paper, we present the result of the first validation simulation study of multi-wavelength PMI that utilizes five different laser wavelengths ranging between 760 and 980 nm. Using the high resolution wavelength specific absorption maps, PMI successfully recovered the concentration of three dyes, used as chromophore in the composition of our phantom, with high spatial resolution and quantitative accuracy. By providing functional information at high resolution, multi-wavelength PMI will be a valuable tool for monitoring tissue physiology, cancer detection and monitoring.

Paper Details

Date Published: 27 February 2019
PDF: 8 pages
Proc. SPIE 10871, Multimodal Biomedical Imaging XIV, 108710F (27 February 2019); doi: 10.1117/12.2504310
Show Author Affiliations
Maha Algarawi, Univ. of California, Irvine (United States)
Farouk Nouizi, Univ. of California, Irvine (United States)
Alex Luk, Univ. of California, Irvine (United States)
Mehrnaz Mehrabi, Univ. of California, Irvine (United States)
Hakan Erkol, Bogaziçi Üniv. (Turkey)
Mehmet Burçin Ünlü, Bogaziçi Üniv. (Turkey)
Gultekin Gulsen, Univ. of California, Irvine (United States)
Seunghoon Ha, Philips Healthcare (United States)

Published in SPIE Proceedings Vol. 10871:
Multimodal Biomedical Imaging XIV
Fred S. Azar; Xavier Intes; Qianqian Fang, Editor(s)

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