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Proceedings Paper

Optical coherence tomography (OCT) examination of living kidney – animal study
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Paper Abstract

Optical coherence tomography (OCT) is an imaging technology which can be used to obtain the high resolution cross sectional image of living biological tissues. It has been used to evaluate the structure and function of animal and human kidneys. Preliminary animal and human data suggest that OCT imaging might be a useful non-invasive tool for characterizing renal tubular lumens, such as the opening status of tubular lumens. In this pilot study, living animal kidneys (dog, rat and mouse) were imaged using a swept source OCT (SS OCT) or spectral domain OCT(SD OCT). In vivo imaging scans were carried out using an OCT microscope setup (5×) and by placing the imaging probe above the surface of the living kidney. Semi-quantitative analysis of the OCT images was performed to evaluate the density of the kidney tubules on the surface layer of the cortex. In addition, histological images of the kidneys were restructured to form nephron three-dimensional structure for comparison with the 3D OCT imaging. This study suggests that quantitative OCT imaging might be useful for visualizing the fine structure of the living kidney and determining the density of renal tubules.

Paper Details

Date Published: 5 November 2018
PDF: 6 pages
Proc. SPIE 10816, Advanced Optical Imaging Technologies, 108160J (5 November 2018); doi: 10.1117/12.2502718
Show Author Affiliations
Weijun Li, Fujian Normal Univ. (China)
Yuhong Fang, Fujian Normal Univ. (China)
Minnan Normal Univ. (China)
Junxia Li, Fuzhou General Hospital of Nanjing Military Command (China)
Wei Gong, Fujian Normal Univ. (China)
Yongzeng Li, Fujian Normal Univ. (China)
Shushen Xie, Fujian Normal Univ. (China)
Zheng Huang, Fujian Normal Univ. (China)
Univ. of Colorado (United States)

Published in SPIE Proceedings Vol. 10816:
Advanced Optical Imaging Technologies
Xiao-Cong Yuan; Kebin Shi; Michael G. Somekh, Editor(s)

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