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Proceedings Paper

Impacts of vascular diameter and depth on singlet oxygen luminescence imaging in tissue simulating phantom
Author(s): Xianglian Liao; Yi Shen; Yunfei Yu; Huiyun Lin; Lisheng Lin; Ying Gu; Buhong Li
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Paper Abstract

Singlet oxygen (1O2) is the primary cytotoxic production in type-II photodynamic therapy (PDT). The correlation between 1O2 generation and PDT efficacy during treatment has received considerable attention. The direct detection of 1O2 luminescence is the gold standard for 1O2 identification. However, the intensity of 1O2 luminescence could be influenced by tissue optical properties, location and morphology of lesion, especially for vascular targeting PDT. In this study, the impacts of vascular diameter and depth on 1O2 luminescence imaging have been investigated in tissue simulating phantom. A near-IR sensitive InGaAs camera with adaptive optics and CW laser 532 nm were used for fast imaging of 1O2 luminescence. Rose Bengal (RB) was used as photosensitizer to generate 1O2 during photosensitization. Intralipid was diluted with different concentrations in order to establish the scattering properties of tissues. The capillary tubes, containing solution of RB, with varied diameters from 0.1 to 0.9 mm were used to simulate the vascular with the depth varied from 0 to 5 mm in phantom. The preliminary results indicate that the profile range ratio of 1O2 luminescence images are negatively correlated to the diameter of capillary tube, and the attenuation of intensity of 1O2 luminescence is non-linear with the increase of depth.

Paper Details

Date Published: 23 October 2018
PDF: 6 pages
Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108203I (23 October 2018); doi: 10.1117/12.2502717
Show Author Affiliations
Xianglian Liao, Fujian Normal Univ. (China)
Yi Shen, Fujian Normal Univ. (China)
Yunfei Yu, Fujian Normal Univ. (China)
Huiyun Lin, Fujian Normal Univ. (China)
Lisheng Lin, Fujian Normal Univ. (China)
Ying Gu, Chinese PLA General Hospital (China)
Buhong Li, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 10820:
Optics in Health Care and Biomedical Optics VIII
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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