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Evaluation of singlet oxygen luminescence of a novel chlorin photosensitizer
Author(s): Jian Zou; Jie Jiang; Zhen Han; Lisheng Lin; Yongzhen Li; Zheng Huang
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Paper Abstract

Photodynamic therapy (PDT) utilizes the combined action of photosensitizer, light and molecular oxygen to generate singlet oxygen to treat various diseases. Photosensitizer is a key component and its optical properties and singlet oxygen quantum yield determine the effectiveness of its photodynamic reaction. This study evaluated the singlet oxygen production of a novel water solubility chlorin photosensitizer - namely YLG-I, which was developed in China. The absorption spectra and singlet oxygen luminescence different solvents were evaluated. It was estimated that the singlet oxygen quantum yield of the new photosensitizer YLG-I was at the same level of the potent chlorin sensitizer mTHPC. Preliminary evaluation suggested that YLG-I was a promising photosensitizer for PDT. This presentation will report the detection of singlet oxygen luminescence of the newly developed PDT sensitizer.

Paper Details

Date Published: 23 October 2018
PDF: 7 pages
Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108203C (23 October 2018); doi: 10.1117/12.2502481
Show Author Affiliations
Jian Zou, Fujian Normal Univ. (China)
Jie Jiang, Fujian Normal Univ. (China)
Zhen Han, Guilin Huing Biopharmaceutical Co., Ltd. (China)
Lisheng Lin, Fujian Normal Univ. (China)
Yongzhen Li, Fujian Normal Univ. (China)
Zheng Huang, Fujian Normal Univ. (China)
Univ. of Colorado Denver (United States)


Published in SPIE Proceedings Vol. 10820:
Optics in Health Care and Biomedical Optics VIII
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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