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In vivo imaging prednisolone-induced osteoporosis of the adult zebrafish with spectral domain optical coherence tomography
Author(s): Yanping Lin; Xiang Xiang; Tingru Chen; Chudan Gao; Hongbo Fu; Limei Wang; Jian Zhang
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Paper Abstract

Osteoporosis studies require precise visualization of the morphological structures. The adult zebrafish represents an excellent model to investigate osteoporosis. However, few imaging methods can effectively detect the adult zebrafish bone structure in real time with high resolution and good penetration depth. In this paper, long-term in vivo monitoring of Prednisolone-induced osteoporosis is achieved with spectral-domain optical coherence tomography (SD-OCT). The SD-OCT is able to noninvasively visualize the skull injury and osteoporosis of adult zebrafish. Valuable phenomenon such as the skull defect and bone loss can be conducted based on the SD-OCT images at different time points during a period of 21 days.

Paper Details

Date Published: 23 October 2018
PDF: 5 pages
Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 1082037 (23 October 2018); doi: 10.1117/12.2502424
Show Author Affiliations
Yanping Lin, Guangzhou Medical Univ. (China)
Xiang Xiang, Guangzhou Medical Univ. (China)
Tingru Chen, Guangzhou Medical Univ. (China)
Chudan Gao, Guangzhou Medical Univ. (China)
Hongbo Fu, Guangzhou Medical Univ. (China)
Limei Wang, Guangdong Institute of Applied Biological Resources (China)
Jian Zhang, Guangzhou Medical Univ. (China)


Published in SPIE Proceedings Vol. 10820:
Optics in Health Care and Biomedical Optics VIII
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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