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Optoelectronic method for increasing the sensibility of mass spectrometer in the case of the determination of papaverine
Author(s): Daniel Petrişor Hristea; Ruxandra Populeanu; Radu Alexandru Macovei; Paul Şchiopu; Marian Vlădescu; Mihai Ionică
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Paper Abstract

Papaverine is an opiate alkaloid used in the primary treatment of visceral spasms, cardiac and cerebral vasospasms, and occasionally for the treatment of erectile dysfunction [1]. Although found in opium poppy, papaverine differs both in structure and pharmacological action for opioid analgesics, morphine and related substances [2].

Papaverine is used to treat gastrointestinal tract spasms, bile ducts, ureters as a cerebral and coronary vasodilator, subarachnoid hemorrhage [3] and a coronary artery bypass [4]. Papaverine is used as a smooth muscle relaxant in microsurgery if it is applied directly to blood vessels. In the treatment of erectile dysfunction, a papaverine gel has recently been used [5]. Also, in combination with other drugs, it is commonly used in cryopreservation of blood vessels [6, 7].

Papaverine is a direct relaxing smooth muscle, which is attributed to its ability to inhibit phosphodiesterase. It can be administered for peripheral cerebral and coronary circulation. It can also be used for vascular disorders, for gastrointestinal disorders as an antispasmodic and against cough. However, its use for the latest recommendations should be regarded with caution [8].

For these reasons, the determination of papaverine in urine samples is very important [2]. Identification is preferably by GC-MS or HPLC-MS chromatographic techniques [9].

Paper Details

Date Published: 31 December 2018
PDF: 4 pages
Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 109773O (31 December 2018); doi: 10.1117/12.2501260
Show Author Affiliations
Daniel Petrişor Hristea, Univ. of Medicine and Pharmacy "Carol Davila" (Romania)
Ruxandra Populeanu, Univ. Politehnica of Bucharest (Romania)
Radu Alexandru Macovei, Univ. of Medicine and Pharmacy "Carol Davila" (Romania)
Clinical Emergency Hospital Bucharest (Romania)
Paul Şchiopu, Univ. Politehnica of Bucharest (Romania)
Marian Vlădescu, Univ. Politehnica of Bucharest (Romania)
Mihai Ionică, Univ. Politehnica of Bucharest (Romania)
Military-Medical Scientific Research Ctr. (Romania)


Published in SPIE Proceedings Vol. 10977:
Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX
Marian Vladescu; Razvan D. Tamas; Ionica Cristea, Editor(s)

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