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Proceedings Paper

Label-free DNA detection based on whispering gallery mode optofluidic microcavity biosensor
Author(s): Liang Fu; Xiaogang Chen; Qijing Lu; Shunsen Xie
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Paper Abstract

We proposed and experimentally demonstrated a sensitive, label-free, real-time and low-cost optofluidic microcavity biosensor for DNA detection. The change of whispering gallery mode (WGM) resonant wavelength is monitored by data acquisition card in real-time. The experimental results show that the biosensor can significantly distinguish the non-complementary single strand (ssDNA), single nucleotide mismatch ssDNA, and target ssDNA. In addition, a sensing mechanism based on WGM coupling depth was also experimentally demonstrated which would have potential for detection of biological and chemical analytes in the future.

Paper Details

Date Published: 25 October 2018
PDF: 6 pages
Proc. SPIE 10823, Nanophotonics and Micro/Nano Optics IV, 108231E (25 October 2018); doi: 10.1117/12.2501139
Show Author Affiliations
Liang Fu, Fujian Normal Univ. (China)
Xiaogang Chen, Fujian Normal Univ. (China)
Qijing Lu, Fujian Normal Univ. (China)
Shunsen Xie, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 10823:
Nanophotonics and Micro/Nano Optics IV
Zhiping Zhou; Kazumi Wada, Editor(s)

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