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Proceedings Paper

Illumination and projection optics for spatial frequency domain fluorescence imaging
Author(s): Chunlin Li; Lina Liu; Lisheng Lin; Ying Gu; Buhong Li
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Paper Abstract

A digital micromirror device (DMD) based structural illumination and projection optical system were designed and evaluated for fluorescence imaging and diffuse reflectance imaging of tissue in spatial frequency domain, respectively. Light emitting diodes (LEDs) at discrete wavelengths (532, 620, 656 nm) provided illumination for the diffuse reflectance imaging while a 532 nm laser diode (LD) was used as excitation light source of photosensitizer (PS) fluorescence. Both the LEDs and LD light were collimated, homogenized and converged on a DMD to generate the structural illumination. A projection lens was also designed to project a rectangular structural illumination spot on target tissue. The designed optical system could be applied to provide variable frequency structural illumination for depth sensitive excitation of PS and diffuse reflectance imaging.

Paper Details

Date Published: 23 October 2018
PDF: 7 pages
Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108202D (23 October 2018); doi: 10.1117/12.2500995
Show Author Affiliations
Chunlin Li, Fujian Normal Univ. (China)
Lina Liu, Fujian Normal Univ. (China)
Lisheng Lin, Fujian Normal Univ. (China)
Ying Gu, Chinese PLA General Hospital (China)
Buhong Li, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 10820:
Optics in Health Care and Biomedical Optics VIII
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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