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Metronidazole-substituted dendrimer silicon phthalocyanine: a novel photodynamic therapy photosensitizer
Author(s): Qiuhao Ye; Xiangyi Han; Di Zeng; Hongqin Yang; Yiru Peng
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Paper Abstract

As an excellent second-generation photosensitizer for photodynamic therapy (PDT), phthalocyanine (Pc) complex has strong absorption peak in the near-infrared region and strong tissue penetrating ability, which endowed them excellent properties for the detection of tumor tissue. In recent years, in order to further ehnaced the penetration depth of the photosensitizer to the tissue, a large number of functional groups have been synthesized . In this work, we designed and synthesized metronidazole-substituted dendrimer silicon phthalocyanine (MT-SiPc) with near-infrared region Q-band of UV absorption, excellent fluorescence properties and photochemical properties.

Paper Details

Date Published: 23 October 2018
PDF: 7 pages
Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 1082029 (23 October 2018); doi: 10.1117/12.2500889
Show Author Affiliations
Qiuhao Ye, Fujian Normal Univ. (China)
Xiangyi Han, Fujian Normal Univ. (China)
Di Zeng, Fujian Normal Univ. (China)
Hongqin Yang, Fujian Normal Univ. (China)
Yiru Peng, Fujian Normal Univ. (China)


Published in SPIE Proceedings Vol. 10820:
Optics in Health Care and Biomedical Optics VIII
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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