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Gold-silver alloy film based surface plasmon resonance sensor for biomarker detection
Author(s): Ru-meng Yi; Zhe Zhang; Chun-xiu Liu; Zhi-mei Qi
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Paper Abstract

In this study, we developed a kind of gold-silver alloy film based SPR (AuAg-SPR) sensors with wavelength interrogation to detect Cancer antigen 125 (CA125) by sandwich immunoassay. The experiment shows that the changes in resonance wavelength (Δλ𝑅) of AuAg-SPR sensors are higher than that of the gold film based SPR (Au-SPR) sensors when the final sandwich structures were formed. We have applied the Fresnel reflection equations and Bruggeman approximation formula to calculate the volume fractions of adsorbates in different adlayers, and the dispersion curves of the effective refractive index (RI) of adsorbates with different volume fractions of adlayers were obtained. Moreover, we simulated the sensitivity of RI of two kinds of sensors by using the waveguide equations, when the initial resonance wavelength (λ𝑅) was fixed at 628nm, changing RI from 1.333 to 1.335, the Δλ𝑅 of AuAg-SPR sensor is 2.25-fold compared with that of Au-SPR sensor. Finally, the effect of the size of antigen on the detection result and effective RI were analyzed. In conclusion, the AuAgSPR sensors with a higher sensitivity than the conventional Au-SPR sensors in detecting CA125, owing to the advantages of low-cost, stability, highly efficient for the clinical determination of CA125 levels

Paper Details

Date Published: 23 October 2018
PDF: 12 pages
Proc. SPIE 10821, Advanced Sensor Systems and Applications VIII, 108210Y (23 October 2018); doi: 10.1117/12.2500802
Show Author Affiliations
Ru-meng Yi, Beijing Jiaotong Univ. (China)
Zhe Zhang, Beijing Jiaotong Univ. (China)
Chun-xiu Liu, Institute of Electronics (China)
Zhi-mei Qi, Institute of Electronics (China)


Published in SPIE Proceedings Vol. 10821:
Advanced Sensor Systems and Applications VIII
Tiegen Liu; Shibin Jiang, Editor(s)

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