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Detection of oligomerization of Epstein-Barr virus oncoprotein LMP1 by FRET-based probes
Author(s): Zhiwei Wu; Qing Ye; Jing Li; Yimei Huang; Yating Lin; Mengmeng Zheng; Shusen Xie; Juqiang Lin
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Paper Abstract

In this study, two FRET-based probes are constructed to research oligomerization of Epstein-Barr virus Oncoprotein LMP1 in live cells. The images of wide-field fluorescence microscopy display that the majority of two LMP1-associated probes co-localized in internal perinuclear membranes. Furthermore, the fluorescence spectra of single cell co-expressed two probes indicated that the ratio of two emission peaks is around one, and the fluorescence spectra changed insignificantly during an hour observation. These findings indicated that LMP1/LMP1 interacted stably in live cells.

Paper Details

Date Published: 23 October 2018
PDF: 6 pages
Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108201T (23 October 2018); doi: 10.1117/12.2500650
Show Author Affiliations
Zhiwei Wu, Fujian Normal Univ. (China)
Qing Ye, Fujian Medical Univ. (China)
Jing Li, Fujian Medical Univ. (China)
Yimei Huang, Fujian Normal Univ. (China)
Yating Lin, Fujian Normal Univ. (China)
Mengmeng Zheng, Fujian Normal Univ. (China)
Shusen Xie, Fujian Normal Univ. (China)
Juqiang Lin, Fujian Normal Univ. (China)


Published in SPIE Proceedings Vol. 10820:
Optics in Health Care and Biomedical Optics VIII
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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