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Label-free detection of the carcinoembryonic antibody protein based MoS2 nanosheets using terahertz spectroscopy
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Paper Abstract

As a new two-dimensional material, MoS2 has been extensively studied in terahertz modulation due to its excellent photoelectric properties. Herein, we studied a novel method for label-free detection of the carcinoembryonic antibody based on MoS2 nanosheets using terahertz spectroscopy. Protein molecules were fabricated on the COC substrates with MoS2 nanosheets. A self-made simple sample cell was used to get signal of protein molecules in a liquid phase. Computational analysis was performed using a classic sandwich structure model. The refractive index and absorption coefficient were calculated. As a result, the THz signal increased with the protein concentration increasing in 0.2-1.1THz. The cole-cole plot was also investigated. The effectiveness of MoS2 nanosheets for adsorbing protein molecules has been demonstrated, which can be used to detect carcinoembryonic antigen sensitively in the future.

Paper Details

Date Published: 9 November 2018
PDF: 8 pages
Proc. SPIE 10826, Infrared, Millimeter-Wave, and Terahertz Technologies V, 1082607 (9 November 2018); doi: 10.1117/12.2500373
Show Author Affiliations
Xingxing Lu, Shenzhen Univ. (China)
Pengfei Xie, Shenzhen Univ. (China)
Yiwen Sun, Shenzhen Univ. (China)


Published in SPIE Proceedings Vol. 10826:
Infrared, Millimeter-Wave, and Terahertz Technologies V
Cunlin Zhang; Xi-Cheng Zhang; Masahiko Tani, Editor(s)

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