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Proceedings Paper

Anti-hepatocarcinoma effects of puerarin-nanoethosomes against human HepG2 cells
Author(s): Xiang-Ping Meng; Jia-min Gao; Tong-sheng Chen; Yi-fei Wang; Zhi-ping Wang
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Paper Abstract

Hepatocarcinoma, a malignant cancer, threaten human life badly. It is a current issue to seek the effective natural remedy from plant to treat cancer due to the resistance of the advanced hepatocarcinoma to chemotherapy. Puerarin (Pue), a major active ingredient in the traditional Chinese medicine Gegen, has a wide range of pharmacological properties and is considered to have anti-hepatocarcinoma effects. However its low oral bioavailability restricts its wide application. In this report, Pue loaded nanoethosomes(Pue-NE) was prepared by high pressure homogenization technique. The in vitro anti-hepatocarcinoma effects of Pue-NE relative to efficacy of bulk Pue were evaluated. The particle size and zeta potential of Pue-NE were 91.8 nm and -6.1 mV, respectively. MTT assay showed that Pue-NE effectively inhibited the proliferation of HepG2 cells, and the corresponding IC50 values of Pue-NE and bulk Pue were 1.77 and 5.73 μg/ml. These results suggest that the delivery of Pue-NE is a promising approach for treating tumors.

Paper Details

Date Published: 25 October 2018
PDF: 6 pages
Proc. SPIE 10823, Nanophotonics and Micro/Nano Optics IV, 1082316 (25 October 2018); doi: 10.1117/12.2500149
Show Author Affiliations
Xiang-Ping Meng, Henan Univ. of Science and Technology (China)
Jia-min Gao, Guangdong Pharmaceutical Univ. (China)
Tong-sheng Chen, South China Normal Univ. (China)
Yi-fei Wang, Jinan Univ. (China)
Zhi-ping Wang, Guangdong Pharmaceutical Univ. (China)

Published in SPIE Proceedings Vol. 10823:
Nanophotonics and Micro/Nano Optics IV
Zhiping Zhou; Kazumi Wada, Editor(s)

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