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Evaluation of free-radical scavenging and antioxidant activities of polydatin nanoethosomes
Author(s): Jia-zhen Du; Jia-Min Gao; Fan Shi; Tong-sheng Chen; Yi-fei Wang; Zhi-ping Wang
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Paper Abstract

Cellular damage induced by free-radicals like reactive oxygen species has been implicated in several diseases. The ROS radicals like alkoxy radical(RO-) and peroxy radical (ROO-) are similar to those that are physiologically active and thus might initiate a cascade of intracellular toxic events leading to DNA damage and cell death. Hence naturally anti-oxidant play a vital role in combating these conditions. In this study, polydatin nanoethosomes (Pol-NE) was prepared by high pressure homogenization technique. The effects of Pol-NE on free radical scavenging and antioxidant was investigated. The particle size and zeta potential of Pol-NE was 96.1±4.5 nm and -17.31±1.67 mV, respectively. By free radical scavenging and antioxidant assays, the IC50 value of Pol-NE were 28.71, 9.83 μg/mL with DPPH, ABTS assay respectively, and 0.143 mg ferrous sulfate/1 mg Pol-NE with FRAP assay. These results indicated that the antioxidant properties of Pol-NE hold great potential used as an alternative to more toxic synthetic anti-oxidants as an additive in food, cosmetic and pharmaceutical preparations for the oxidative diseases treatment.

Paper Details

Date Published: 25 October 2018
PDF: 7 pages
Proc. SPIE 10823, Nanophotonics and Micro/Nano Optics IV, 1082315 (25 October 2018); doi: 10.1117/12.2500148
Show Author Affiliations
Jia-zhen Du, Jinan Univ. (China)
Jia-Min Gao, Guangdong Pharmaceutical Univ. (China)
Fan Shi, Guangdong Pharmaceutical Univ. (China)
Tong-sheng Chen, South China Normal Univ. (China)
Yi-fei Wang, Jinan Univ. (China)
Zhi-ping Wang, Guangdong Pharmaceutical Univ. (China)


Published in SPIE Proceedings Vol. 10823:
Nanophotonics and Micro/Nano Optics IV
Zhiping Zhou; Kazumi Wada, Editor(s)

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