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Proceedings Paper

Planar waveguide optical immunosensors
Author(s): Steven J. Choquette; Laurie E. Locascio-Brown; Richard A. Durst
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Paper Abstract

Monoclonal antibodies were covalently bonded to the surfaces of planar waveguides to confer immunoreacth''ity. Silver-ion diffused waveguides were used to measure theophylline concentrations in a fluorescence immunoassay and silicon nitride waveguides were used to detect theophylline in an absorbance-based immunoassay. Liposomes were employed in both assays as the optically detectable label in a competitive reaction to monitor antigen-antibody complexation. Regeneration of the active antibody site will be discussed.

Paper Details

Date Published: 1 March 1991
PDF: 6 pages
Proc. SPIE 1368, Chemical, Biochemical, and Environmental Fiber Sensors II, (1 March 1991); doi: 10.1117/12.24803
Show Author Affiliations
Steven J. Choquette, National Institute of Standards and Technology (United States)
Laurie E. Locascio-Brown, National Institute of Standards and Technology (United States)
Richard A. Durst, National Institute of Standards and Technology (United States)


Published in SPIE Proceedings Vol. 1368:
Chemical, Biochemical, and Environmental Fiber Sensors II
Robert A. Lieberman; Marek T. Wlodarczyk, Editor(s)

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