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Proceedings Paper

Integrated optic device for biochemical sensing
Author(s): Anthony A. Boiarski; Richard W. Ridgway; Larry S. Miller; Ballwant S. Bhullar
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Paper Abstract

A novel immunosensor concept monitors antigen-antibody binding on the surface of a planar single-mode waveguide. The concept can be used as the basis for a label-free homogeneous immunoassay because only changes in the thickness and refractive index of the antigen-antibody layer are monitored by observing small changes in the effective index of the waveguide. BSA +anti- BSA binding was examined theoretically using a four-layer model and effective index measurements were obtained which agreed with the calculated values. Analysis indicated that the small effective index changes can possibly be measured with high sensitivity and at low cost using an integrated optic interferometer format.

Paper Details

Date Published: 1 March 1991
PDF: 9 pages
Proc. SPIE 1368, Chemical, Biochemical, and Environmental Fiber Sensors II, (1 March 1991); doi: 10.1117/12.24797
Show Author Affiliations
Anthony A. Boiarski, Battelle Memorial Institute (United States)
Richard W. Ridgway, Battelle Memorial Institute (United States)
Larry S. Miller, Battelle Memorial Institute (United States)
Ballwant S. Bhullar, Battelle Memorial Institute (United States)

Published in SPIE Proceedings Vol. 1368:
Chemical, Biochemical, and Environmental Fiber Sensors II
Robert A. Lieberman; Marek T. Wlodarczyk, Editor(s)

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